Endocrine Abstracts

Objectives: The primary objective was to determine if the use of Contour Next One (CNO) with Contour Diabetes app (APP) was associated with improved self-management using the Summary of Diabetes Self-Care Activities questionnaire (SDSCA). A secondary objective was to establish if CNO and APP together had impact on adherence to self-monitoring blood glucose (BG), indicated by frequency of BG readings and hypoglycemic events. Other secondary objectives were to observe a possible...

Introduction: p53 is transcription factor widely known because of its antitumoral actions. New evidences suggest that p53 also play a key role in the regulation of metabolic homeostasis and specifically in the lipid metabolism.Objective: We hypothesize that the chemical activation of p53 with low doses of doxorubicin could ameliorate the lipid metabolism in in vitro models of liver steatosis.Methods: We treated with low co...

Introduction: Obesity is a global health challenge with more than 60% of the world´s population with obesity living in LMICs. Studies have demonstrated that women are more affected by obesity than men. However, the risk of obesity and obesity-related cardiometabolic diseases in women in LMICs have not been documented. The aims of this meta-analysis are: to evaluate the risk of obesity and obesity-related cardiometabolic disease in women compared to men in LMICs and to eva...

Background: Patients with Cushing’s syndrome (CS) in remission show residual cardiometabolic derangements leading to increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis), such as richness, diversity and composition, have been associated with several cardiometabolic risk factors, including obesity, insulin resistance and atherosclerosis. Whether CS patients present with intestinal dysbiosis is currently unknown. Our study was aimed at evalu...

Introduction: COVID-19 has taken on pandemic proportions. Phase angle (PhA) and Standardized phase angle (SPhA) have been related to mortality and severity in several diseases.Objetives: To determine the predictive role of PhA and SPhA on 90 days survival of adults with COVID-19.Methods: A longitudinal cohort study with 127 consecutive patients diagnosed with COVID-19. We collected PhA, SPhA, body composition (fat mass, fat free ma...

Backgrounds: One of the most observations in subjects with obesity, is a high prevalence of vitamin D deficiency, which, in turn, it has been implicated with decreased testosterone levels and an increased hypogonadism risk. Testosterone deficiency is a very common feature in males with obesity. However, only few studies have investigated the effect of vitamin D on testosterone in the context of obesity, and controversial results has been found.Hypothesis...

Introduction: To determine the risk of recurrence in DTC, different clinical factors have been used (presence of adenopathies, extrathyroid extension, histology\..). The objective was to examine whether the value of early postoperative Tg concentration may also predict long-term recurrence of DTC.Material and Methods: The study included 249 consecutive patients (78.3% women, mean age 50.72 ± 14.26 years) with DTC who were initially treated by total ...

Introduction: For the clinical diagnosis of heterozygous familial hypercholesterolemia (HeFH) validated algorithms are used, with the Dutch Lipid Clinic Network (DLCN) Criteria being the most recommended in our environment. One of the items that scores for the system proposed by the DLCN is the value of LDL cholesterol. However, LDLc levels can be distorted by lipoprotein a (Lpa(a)) levels.Objective: To analyze the change in the validity of the DLCN crit...

Introduction: Body composition is gaining great interest in some pathologies such as Type 1 Diabetes Mellitus (DM1). Adherence to the Mediterranean diet has been shown to be effective in improving the prognosis of cardiovascular disease, which is the main cause of mortality in these patients.Objectives: To assess whether adherence to the Mediterranean diet in DM1 is associated with improvement in disease control parameters, body composition, anthropometr...

Background and aims: Transition of patients with type 1 diabetes (DM1) from pediatric to adult care is challenging and international guidelines recommend effective transition programs. The aim of this study is to describe our baseline situation, without a structured transition program, and to identify factors associated with worse glycemic outcome.Materials and Methods: This is an observational, retrospective study of patients with DM1, aged 14 or more o...